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Spicy Buffalo 5-Cheese Mac & Cheese Penne Pasta calories & nutrition
The Domino's Spicy Buffalo 5-Cheese Mac & Cheese Penne Pasta has 840 calories, 31 g protein, 64 g carbs and 50 g fat.
Nutrition Facts
* Percent Daily Values are based on a 2,000 calorie diet (FDA). Values from the chain's published nutrition, 2026 menu.
Good for weight loss?
It is a heavy pick: 840 calories is 42% of a 2,000 calorie day. The Chicken Alfredo Penne Pasta has 590 calories with 24 g of protein.
#62 of 65 Domino's meals by protein per calorie.
Lighter swaps at Domino's
Fewer calories, similar protein
 Chicken Alfredo Penne PastaOven-Baked Pastas | 590 | 24 g | 60 g | 28 g | 1,020 mg |
|---|---|---|---|---|---|
 5-Cheese Mac & Cheese Penne PastaOven-Baked Pastas | 830 | 30 g | 64 g | 50 g | 1,680 mg |
 Chicken Parm SandwichOven-Baked Sandwiches · 1/2 Sandwich | 400 | 25 g | 38 g | 15 g | 1,050 mg |
Questions
How many calories are in the Domino's Spicy Buffalo 5-Cheese Mac & Cheese Penne Pasta?
The Domino's Spicy Buffalo 5-Cheese Mac & Cheese Penne Pasta has 840 calories, on the 2026 menu.
How much protein is in the Spicy Buffalo 5-Cheese Mac & Cheese Penne Pasta?
31 g of protein, or 3.7 g for every 100 calories. That ranks #62 of 65 Domino's meals by protein per calorie.
How many carbs and how much fat are in the Spicy Buffalo 5-Cheese Mac & Cheese Penne Pasta?
64 g of carbs (2 g fiber, 6 g sugar) and 50 g of fat.
How much sodium is in the Spicy Buffalo 5-Cheese Mac & Cheese Penne Pasta?
2,090 mg, 91% of the 2,300 mg daily limit in the Dietary Guidelines for Americans.
Is the Domino's Spicy Buffalo 5-Cheese Mac & Cheese Penne Pasta good for weight loss?
It is a heavy pick: 840 calories is 42% of a 2,000 calorie day. The Chicken Alfredo Penne Pasta has 590 calories with 24 g of protein.
Eat at Domino's. Still lose weight.
At Domino's, the Ham & Bacon Breakfast Pizza, Medium Hand Tossed is 250 calories and the Spicy Buffalo 5-Cheese Mac & Cheese Penne Pasta is 840. MenuTrim builds your personal plan and shows which one fits today.
- Daily calories for your goalFrom your weight, goal weight and pace.
- A protein target and a per-meal limitSo one meal out doesn't take the whole day.
- The date you'll reach your goalAn estimate from your pace, updated as you log.
- Domino's orders that fit, marked15,000+ dishes at 50 chains, all from 2026 menus.
Build your plan in the app.Nutrition from Domino's's published information for the 2026 menu. Recipes change; check with the restaurant if it matters. MenuTrim is not affiliated with Domino's.