MenuTrim
Ultimate Pepperoni Hand Tossed Pizza, Medium calories & nutrition
The Domino's Ultimate Pepperoni Hand Tossed Pizza, Medium has 420 calories, 17 g protein, 38 g carbs and 21 g fat (Medium).
Nutrition Facts
* Percent Daily Values are based on a 2,000 calorie diet (FDA). Values from the chain's published nutrition, 2026 menu.
Good for weight loss?
It can fit. 420 calories is 21% of a 2,000 calorie day; pair it with a light breakfast and dinner, and skip the soda and fries.
#48 of 65 Domino's meals by protein per calorie.
Lighter swaps at Domino's
Fewer calories, similar protein
 Breakfast Pizza, Large Hand TossedSpecialty Pizzas · 1/8 pizza | 320 | 16 g | 33 g | 14 g | 710 mg |
|---|---|---|---|---|---|
Ham & Bacon Breakfast Pizza, Large Hand TossedSpecialty Pizzas · 1/8 pizza | 330 | 15 g | 32 g | 14 g | 740 mg |
 Honolulu Hawaiian Hand Tossed Pizza, MediumSpecialty Pizzas · Medium | 380 | 17 g | 40 g | 17 g | 910 mg |
More protein for about the same calories
 Chicken Parm SandwichOven-Baked Sandwiches · 1/2 Sandwich | 400 | 25 g | 38 g | 15 g | 1,050 mg |
|---|---|---|---|---|---|
 Chicken Bacon Ranch SandwichOven-Baked Sandwiches · 1/2 Sandwich | 450 | 23 g | 37 g | 22 g | 1,190 mg |
 Italian SandwichOven-Baked Sandwiches · 1/2 Sandwich | 420 | 21 g | 37 g | 20 g | 1,530 mg |
Questions
How many calories are in the Domino's Ultimate Pepperoni Hand Tossed Pizza, Medium?
The Domino's Ultimate Pepperoni Hand Tossed Pizza, Medium has 420 calories (Medium), on the 2026 menu.
How much protein is in the Ultimate Pepperoni Hand Tossed Pizza, Medium?
17 g of protein, or 4.0 g for every 100 calories. That ranks #48 of 65 Domino's meals by protein per calorie.
How many carbs and how much fat are in the Ultimate Pepperoni Hand Tossed Pizza, Medium?
38 g of carbs (1 g fiber, 3 g sugar) and 21 g of fat.
How much sodium is in the Ultimate Pepperoni Hand Tossed Pizza, Medium?
960 mg, 42% of the 2,300 mg daily limit in the Dietary Guidelines for Americans.
Is the Domino's Ultimate Pepperoni Hand Tossed Pizza, Medium good for weight loss?
It can fit. 420 calories is 21% of a 2,000 calorie day; pair it with a light breakfast and dinner, and skip the soda and fries.
Eat at Domino's. Still lose weight.
At Domino's, the Ham & Bacon Breakfast Pizza, Medium Hand Tossed is 250 calories and the Spicy Buffalo 5-Cheese Mac & Cheese Penne Pasta is 840. MenuTrim builds your personal plan and shows which one fits today.
- Daily calories for your goalFrom your weight, goal weight and pace.
- A protein target and a per-meal limitSo one meal out doesn't take the whole day.
- The date you'll reach your goalAn estimate from your pace, updated as you log.
- Domino's orders that fit, marked15,000+ dishes at 50 chains, all from 2026 menus.
Build your plan in the app.Nutrition from Domino's's published information for the 2026 menu. Recipes change; check with the restaurant if it matters. MenuTrim is not affiliated with Domino's.